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Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon‐Nanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones
Author(s) -
de Carvalho Renato L.,
Jardim Guilherme A. M.,
Santos Augusto C. C.,
Araujo Maria H.,
Oliveira Willian X. C.,
Bombaça Ana Cristina S.,
MennaBarreto Rubem F. S.,
Gopi Elumalai,
Gravel Edmond,
Doris Eric,
da Silva Júnior Eufrânio N.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802773
Subject(s) - rhodium , hydrogen peroxide , aryl , catalysis , carbon nanotube , chemistry , ring (chemistry) , hexane , combinatorial chemistry , organic chemistry , nanotechnology , materials science , alkyl
Abstract This work reports a combination of aryl diselenides/hydrogen peroxide and carbon‐nanotube (CNT)/rhodium nanohybrids (RhCNT) for naphthol oxidation towards the synthesis of 1,4‐naphthoquinones and evaluation of their relevant trypanocidal activity. Under a combination of (PhSe) 2 /H 2 O 2 in the presence of O 2 in i PrOH/hexane, several benzenoid (A‐ring)‐substituted quinones were prepared in moderate to high yields. We also studied the contribution of RhCNT as co‐catalyst in this process and, in some cases, yields were improved. This method provides an efficient and versatile alternative for preparing A‐ring‐modified naphthoquinonoid compounds with relevant biological profile.