Premium
Cover Feature: Unveiling the Binding Modes of the Crystallophore, a Terbium‐based Nucleating and Phasing Molecular Agent for Protein Crystallography (Chem. Eur. J. 39/2018)
Author(s) -
Engilberge Sylvain,
Riobé François,
Wagner Tristan,
Di Pietro Sebastiano,
Breyton Cécile,
Franzetti Bruno,
Shima Seigo,
Girard Eric,
Dumont Elise,
Maury Olivier
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802734
Subject(s) - terbium , supramolecular chemistry , crystallography , crystallization , dimer , cover (algebra) , nucleation , phaser , chemistry , crystal (programming language) , crystal structure , materials science , chemical physics , physics , computer science , engineering , organic chemistry , mechanical engineering , ion , programming language , optics
The first clues on the origins of the peculiar abilities of crystallophore (Tb‐Xo4) are reported. Tb‐Xo4 is a terbium complex that allows both the nucleation of protein crystals and the solving of their structures. Herein, a detailed study of the binding of Tb‐Xo4 in a set of six structures is presented. It evidences the adaptability of the complex towards different crystallization conditions and protein environments, thanks to a variety of supramolecular interactions. The cover shows Tb‐Xo4/FprA protein co‐crystals and the related crystal packing that has been determined. The magnifying glass depicts a detailed view of a Tb‐Xo4 dimer binding site. More information can be found in the Communication by O. Maury, F. Riobé, E. Girard, E. Dumont, et al. on page 9739.