Premium
Ionic Co‐Crystal Formation as a Path Towards Chiral Resolution in the Solid State
Author(s) -
Shemchuk Oleksii,
Tsenkova Boryana K.,
Braga Dario,
Duarte M. Teresa,
André Vânia,
Grepioni Fabrizia
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802446
Subject(s) - enantiopure drug , chirality (physics) , ionic bonding , chemistry , molecule , crystal (programming language) , crystallography , lithium (medication) , proline , lanthanide , stereochemistry , ion , organic chemistry , enantioselective synthesis , amino acid , catalysis , medicine , biochemistry , chiral symmetry breaking , physics , quantum mechanics , endocrinology , quark , computer science , nambu–jona lasinio model , programming language
The preparation and characterization of a whole family of hydrated ionic co‐crystals formed by both enantiopure l ‐proline and racemic dl ‐proline with LiX (X=Cl, Br, I) are reported. The chiral preference of the lithium cation for homochiral coordination, both in the formation of crystalline conglomerates (with Cl and Br) and racemates (with Cl and I), in which molecules of opposite chirality are confined to distinct crystal layers, is discussed. Dehydration processes for all hydrated crystals have also been investigated.