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Non‐Covalent Interactions of a Neuroprotective Peptide Revealed by Photodissociative Cross‐Linking in the Gas Phase
Author(s) -
Liu Yang,
Ramey Zachary,
Tureček František
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802174
Subject(s) - peptide , diazirine , neuroprotection , chemistry , covalent bond , gas phase , amino acid residue , peptide sequence , stereochemistry , biophysics , biochemistry , biology , organic chemistry , pharmacology , gene
The small neuroprotective peptide Cys‐Ala‐Gln‐Lys (CAQK) was selectively tagged with a diazirine group and its photochemical cross‐linking was studied with model target peptides. Experimental results in combination with Born–Oppenheimer molecular dynamics revealed the structural preferences for binding to the amino acid residues in the target peptides. Effects of the target peptide sequence and N‐ and C‐terminal modifications are discussed.