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Unveiling the Binding Modes of the Crystallophore, a Terbium‐based Nucleating and Phasing Molecular Agent for Protein Crystallography
Author(s) -
Engilberge Sylvain,
Riobé François,
Wagner Tristan,
Di Pietro Sebastiano,
Breyton Cécile,
Franzetti Bruno,
Shima Seigo,
Girard Eric,
Dumont Elise,
Maury Olivier
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802172
Subject(s) - terbium , phaser , supramolecular chemistry , lanthanide , crystallography , nucleation , chemistry , diffraction , crystal structure , materials science , nanotechnology , physics , luminescence , ion , organic chemistry , optics , optoelectronics
Crystallophores are lanthanide complexes that act as powerful auxiliary for protein crystallography due to their strong nucleating and phasing effects. To get first insights on the mechanisms behind nucleation induced by Crystallophore, we systematically identified various elaborated networks of supramolecular interactions between Tb‐Xo4 and subset of 6 protein structures determined by X‐ray diffraction in complex with terbium–Crystallophore (Tb‐Xo4). Such interaction mapping analyses demonstrate the versatile binding behavior of the Crystallophore and pave the way to a better understanding of its unique properties.