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Iodonium Salts as Benzyne Precursors
Author(s) -
Yoshimura Akira,
Saito Akio,
Zhdankin Viktor V.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201802111
Subject(s) - aryne , hypervalent molecule , chemistry , reactivity (psychology) , iodine , combinatorial chemistry , computational chemistry , organic chemistry , medicine , alternative medicine , pathology
Abstract Reactions involving benzyne and aryne intermediates have found widespread application in organic synthesis. Various benzyne precursors and benzyne generating procedures are known. Recently, methods of benzyne generation from diaryliodonium salts and related hypervalent iodine compounds have received considerable attention. These methods are characterized by mild reaction conditions and applicability in a broad range of chemical transformations. The present minireview is focused on the preparation and reactivity of hypervalent iodine based benzyne precursors. Furthermore, recent developments in their synthetic application are discussed.