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Cover Feature: Light‐Controlled Simultaneous “On Demand” Release of Cytotoxic Combinations for Bimodal Killing of Cancer Cells (Chem. Eur. J. 30/2018)
Author(s) -
Tessaro André Luiz,
Fraix Aurore,
Failla Mariacristina,
Cardile Venera,
Graziano Adriana C. E.,
Estevão Bianca Martins,
Rescifina Antonio,
Sortino Salvatore
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801943
Subject(s) - cytotoxic t cell , photosensitizer , chlorambucil , singlet oxygen , chemistry , cancer cell , photoexcitation , photodynamic therapy , poloxamer , biophysics , cancer , cancer research , photochemistry , biochemistry , copolymer , biology , oxygen , chemotherapy , excited state , in vitro , organic chemistry , physics , polymer , nuclear physics , cyclophosphamide , genetics
Core‐shell micelles of pluronic copolymers co‐entrap a benzoporphyrin photosensitizer and the chemotherapeutic Chlorambucil, which is temporarily inactivated, through a coumarin photocage. Photoexcitation of this nanoassembly with visible light leads to the simultaneous generation of cytotoxic singlet oxygen and the uncaging of the chemotherapeutic in its active form, resulting in an amplified anticancer activity against MCF‐7 human breast adenocarcinoma cells. More information can be found in the Full Paper by S. Sortino et al. on page 7664.