Premium
N ‐Arylamines Coupled with Aldehydes, Ketones, and Imines by Means of Photocatalytic Proton‐Coupled Electron Transfer
Author(s) -
Xia Qing,
Tian Hao,
Dong Jianyang,
Qu Yi,
Li Lili,
Song Hongjian,
Liu Yuxiu,
Wang Qingmin
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801886
Subject(s) - umpolung , chemistry , photocatalysis , vicinal , electron transfer , brønsted–lowry acid–base theory , catalysis , proton , proton coupled electron transfer , molecule , combinatorial chemistry , photoredox catalysis , organic chemistry , photochemistry , nucleophile , physics , quantum mechanics
A photoredox‐catalyzed umpolung strategy for coupling reactions between aldehydes, ketones, imines, and N ‐arylamines is reported. These reactions proceed by a Brønsted acid‐activated proton‐coupled electron transfer pathway, and the protocol was used to synthesize a broad scope of 1,2‐amino alcohols and vicinal diamines, both of which are common motifs in biologically active natural products, pharmaceutically active molecules, and ligands.