Premium
Bismuth Phosphinates in Bi‐Nanocellulose Composites and their Efficacy towards Multi‐Drug Resistant Bacteria
Author(s) -
Werrett Melissa V.,
Herdman Megan E.,
Brammananth Rajini,
Garusinghe Uthpala,
Batchelor Warren,
Crellin Paul K.,
Coppel Ross L.,
Andrews Philip C.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801803
Subject(s) - nanocellulose , cellulose , bismuth , staphylococcus aureus , bacteria , antibacterial activity , nuclear chemistry , antimicrobial , chemistry , escherichia coli , bacterial cellulose , microbiology and biotechnology , organic chemistry , biology , biochemistry , gene , genetics
A series of poorly soluble phenyl bis ‐phosphinato bismuth(III) complexes [BiPh(OP(=O)R 1 R 2 ) 2 ] (R 1 =R 2 =Ph; R 1 =R 2 = p ‐OMePh; R 1 =R 2 = m ‐NO 2 Ph; R 1 =Ph, R 2 =H; R 1 =R 2 =Me) have been synthesised and characterised, and shown to have effective antibacterial activity against Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ), methicillin‐resistant Staphylococcus aureus (MRSA) and vancomycin‐resistant Enterococcus (VRE). The bismuth complexes were incorporated into microfibrillated (nano‐) cellulose generating a bismuth‐cellulose composite as paper sheets. Antibacterial evaluation indicates that the Bi‐cellulose materials have analogous or greater activity against Gram positive bacteria when compared with commercial silver based additives: silver sulfadiazine loaded at 0.43 wt % into nanocellulose produces a 10 mm zone of inhibition on the surface of agar plates containing S. aureus whereas [BiPh(OP(=O)Ph 2 ) 2 ] loaded at 0.34 wt % produces an 18 mm zone of inhibition. These phenyl bis ‐phosphinato bismuth(III) complexes show potential to be applied in materials in healthcare facilities, to inhibit the growth of bacteria capable of causing serious disease.