Premium
Donor‐influenced Structure–Activity Correlations in Stoichiometric and Catalytic Reactions of Lithium Monoamido‐Monohydrido‐Dialkylaluminates
Author(s) -
Lemmerz Lara E.,
McLellan Ross,
Judge Neil R.,
Kennedy Alan R.,
Orr Samantha A.,
Uzelac Marina,
Hevia Eva,
Robertson Stuart D.,
Okuda Jun,
Mulvey Robert E.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801541
Subject(s) - phenylacetylene , hydroboration , chemistry , deprotonation , bifunctional , substituent , catalysis , medicinal chemistry , lithium (medication) , reactivity (psychology) , organic chemistry , medicine , ion , alternative medicine , pathology , endocrinology
A series of heteroleptic monoamido‐monohydrido‐dialkylaluminate complexes of general formula [ i Bu 2 AlTMPHLi⋅donor] were synthesized and characterised in solution and in the solid state. Applying these complexes in catalytic hydroboration reactions with representative aldehydes and ketones reveals that all are competent, however a definite donor substituent effect is discernible. The bifunctional nature of the complexes is also probed by assessing their performance in metallation of a triazole and phenylacetylene and addition across pyrazine. These results lead to an example of phenylacetylene hydroboration, which likely proceeds via deprotonation, rather than insertion as observed with the aldehydes and ketones. Collectively, the results emphasise that reactivity is strongly influenced by both the mixed‐metal constitution and mixed‐ligand constitution of the new aluminates.