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Ruthenium(II)‐Catalyzed Dearomatized C−H Activation and Annulation Reaction of Vinylnaphthols with Alkynes: Access to Spiro‐Pentacyclic Naphthalenones
Author(s) -
Duarah Gauri,
Kaishap Partha P.,
Sarma Bipul,
Gogoi Sanjib
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801537
Subject(s) - annulation , ruthenium , catalysis , alkyne , chemistry , medicinal chemistry , organic chemistry , combinatorial chemistry
The ruthenium(II)‐catalyzed annulation of vinylnaphthols and alkynes is described. The reaction proceeds through C−H activation, dearomatization, and alkyne insertion. This reaction affords spiro‐pentacyclic naphthalenones that have biological significance in good yields.