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Intelligent Metal Carbonyl Metal–Organic Framework Nanocomplex for Fluorescent Traceable H 2 O 2 ‐Triggered CO Delivery
Author(s) -
Jin Zhaokui,
Zhao Penghe,
Zhang Junheng,
Yang Tian,
Zhou Gaoxin,
Zhang Daohong,
Wang Tianfu,
He Qianjun
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801407
Subject(s) - metal organic framework , fluorescence , materials science , metal , adsorption , nanotechnology , biophysics , chemistry , photochemistry , organic chemistry , physics , biology , quantum mechanics , metallurgy
The recognized therapeutic benefits from carbon monoxide (CO) have caused booming attention to develop a CO therapy for various major diseases, such as cancer. However, the controlled release of CO gas and the monitoring of the CO release are vitally important to the on‐demand CO administration for a safe and efficient therapy, but greatly challenging. In this work, a new CO‐releasing nanocomplex was constructed by the adsorption and coordination of manganese carbonyl ([MnBr(CO) 5 ], abbreviated as MnCO) with a Ti‐based metal–organic framework (Ti‐MOF) to realize an intratumoral H 2 O 2 ‐triggered CO release and real‐time CO release monitoring by fluorescence imaging. A high CO prodrug loading capacity (0.532 g MnCO per gram Ti‐MOF) is achieved due to the high surface area of Ti‐MOF, and the intracellular H 2 O 2 ‐triggered CO release from the MnCO@Ti‐MOF is realized to enable the nanocomplex selectively release CO in tumor cells and kill tumor cells rather than normal cells. Particularly significant is that the real‐time fluorescence imaging monitoring of the CO release is realized based on an annihilation effect of the fluorescence after MnCO loading into Ti‐MOF and an activation effect of the fluorescence after CO release from Ti‐MOF. The quantitative relationship between the fluorescence intensity and the released CO amount is established in great favor of guiding on‐demand CO administration. The results demonstrate the advantage of versatile MOFs for high efficient CO delivery and monitoring, which is critical for the improvement of the effectiveness of future therapeutic application.