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Copper Promoted Regio‐ and Stereoselective Aminochlorination of Alkynes and Alkenes with NFSI
Author(s) -
Wang Weilin,
Liu Lingyan,
Chang Weixing,
Li Jing
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801262
Subject(s) - chemistry , stereoselectivity , copper , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
A simple and rapid copper‐promoted aminochlorination of unactivated alkynes and alkenes with N ‐fluorobenzenesulfonimide (NFSI) was developed. Two series of chloroenamines and chloroamines were obtained in good to high yields. The chlorinated enamines could be obtained in a single E configuration. This reaction involved a radical process and the CuCl 2 acted as the Cl source and NFSI as the N source.