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Catalytic C−C Bond Formation Using a Simple Nickel Precatalyst System: Base‐ and Activator‐Free Direct C‐Allylation by Alcohols and Amines
Author(s) -
Sweeney Joseph B.,
Ball Anthony K.,
Smith Luke J.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801241
Subject(s) - catalysis , chemistry , nickel , activator (genetics) , bond cleavage , combinatorial chemistry , polymer chemistry , organic chemistry , biochemistry , gene
A “totally catalytic” nickel(0)‐mediated method for base‐free direct alkylation of allyl alcohols and allyl amines is reported. The reaction is selective for monoallylation, uses an inexpensive Ni II precatalyst system, and requires no activating reagents to be present.