Premium
Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides
Author(s) -
Zhersh Sergey A.,
Blahun Oleksandr P.,
Sadkova Iryna V.,
Tolmachev Andrey A.,
Moroz Yurii S.,
Mykhailiuk Pavel K.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801140
Subject(s) - reductive amination , protecting group , chemistry , acylation , nitrogen atom , group (periodic table) , amination , sulfonamide , combinatorial chemistry , organic chemistry , catalysis , alkyl
Cyclic saturated aminosulfonyl fluorides were synthesized as their HCl salts. The compounds were found to be stable upon storage and could be used for the protecting‐group‐free synthesis of sulfonamides. In the presence of the −SO 2 F group, the nitrogen atom could be modified by means of acylation, arylation, or reductive amination to give products that have high potential for the synthesis of bioactive compounds.