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Towards Sustainable C−H Functionalization Reactions: The Emerging Role of Bio‐Based Reaction Media
Author(s) -
Santoro Stefano,
Marrocchi Assunta,
Lanari Daniela,
Ackermann Lutz,
Vaccaro Luigi
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801114
Subject(s) - surface modification , biochemical engineering , combinatorial chemistry , key (lock) , nanotechnology , chemistry , computer science , materials science , engineering , computer security
In the last decade, transition‐metal catalyzed C−H functionalization reactions have progressed enormously, becoming a useful tool in organic synthesis and a practical alternative to well‐established methodologies. Very recently, research efforts have also been devoted to developing more sustainable C−H functionalization protocols, in order to increase their applicability. One of the most promising approaches in this sense is represented by the substitution of common reaction media with bio‐based solvents. In the present contribution a general perspective on the benefits of this approach is given, followed by key literature examples.