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Cover Feature: Synthesis of a Novel Type of 2,3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles (Chem. Eur. J. 23/2018)
Author(s) -
Cooper Lisa,
Alonso José Miguel,
Eagling Louise,
Newson Helen,
Herath Sachini,
Thomson Christopher,
Lister Andrew,
Howsham Catherine,
Cox Brian,
Muñoz María Paz
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201801038
Subject(s) - platinum , indole test , nucleophile , context (archaeology) , chemistry , reactivity (psychology) , cover (algebra) , combinatorial chemistry , catalysis , stereochemistry , organic chemistry , engineering , biology , medicine , mechanical engineering , paleontology , alternative medicine , pathology
Organometallic synthesis is a powerful tool to make novel molecules with frameworks not encountered in natural products. In this context the platinum‐catalysed reaction of indolylallenes with indole nucleophiles was discovered which gives substituted tetrahydropyrido[1,2a]indoles, an original type of 2,3′‐BIM with a framework not observed thus far in nature and of interest to the pharmaceutical industry. The reaction is unique to platinum catalysis and the study of the mechanism uncovered a complex reaction pathway that may help in the understanding of the divergent reactivity of platinum compared to other metals. More information can be found in the Full Paper by M. P. Muñoz, et al. on page 6105.