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Transition‐Metal‐Catalyzed C−H Functionalization for Construction of Quaternary Carbon Centers
Author(s) -
Li Yang,
Xu Silong
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800921
Subject(s) - surface modification , quaternary carbon , carbon atom , carbon fibers , transition metal , catalysis , combinatorial chemistry , nanotechnology , chemistry , materials science , organic chemistry , engineering , chemical engineering , enantioselective synthesis , alkyl , composite number , composite material
Efficient construction of quaternary carbon centers represents one of the most challenging goals in organic synthesis, and it has drawn tremendous research interest from organic chemist community. The past decade has witnessed a significant advancement of direct C−H functionalization, which delivers various synthetic tools for assembling structurally diversified architectures with the advantage of step‐ and atom‐economy, operational simplicity, and readily available substrates. In this Minireview, synthetic methods based on transition‐metal‐catalyzed C−H functionalization as efficient tools for the construction of quaternary carbon centers are summarized.