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The Expanding Utility of Rhodium‐Iminocarbenes: Recent Advances in the Synthesis of Natural Products and Related Scaffolds
Author(s) -
Li Yun,
Yang Hongjian,
Zhai Hongbin
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800689
Subject(s) - rhodium , natural (archaeology) , chemistry , nanotechnology , materials science , history , catalysis , organic chemistry , archaeology
Rhodium‐iminocarbenes that are derived from N ‐sulfonyl‐1,2,3‐triazoles have become an important class of reactive species and useful intermediates in organic synthesis. Over the last several years, many practical and versatile approaches involving rhodium‐iminocarbene intermediates to synthetically challenging molecules (scaffolds) have been developed. This Minireview mainly summarizes the recent advance of rhodium‐iminocarbene involved reactions in the synthesis of natural products and their related scaffolds by the end of 2017. Several applications in important pharmaceuticals are documented as well.