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Improvement of Photodynamic Activity of Lipid–Membrane‐Incorporated Fullerene Derivative by Combination with a Photo‐Antenna Molecule
Author(s) -
Antoku Daiki,
Satake Shuhei,
Mae Tomoya,
Sugikawa Kouta,
Funabashi Hisakage,
Kuroda Akio,
Ikeda Atsushi
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800674
Subject(s) - photodynamic therapy , fullerene , derivative (finance) , molecule , photochemistry , absorbance , membrane , chlorin , antenna effect , materials science , chemistry , antenna (radio) , lipid bilayer , liposome , photosensitizer , nanotechnology , optoelectronics , organic chemistry , luminescence , chromatography , biochemistry , telecommunications , computer science , financial economics , economics
The weak absorbance of pristine C 60 , C 70 , and fullerene derivatives at wavelengths over 600 nm hampers the use of these molecules as photosensitizers (PSs) for photodynamic therapy (PDT). The coexistence of light‐harvesting antenna molecules with a fullerene derivative in lipid membrane bilayers solved this issue. By controlling the location of the C 60 derivative in the lipid membrane, the liposomal dyad system for PDT improved the photodynamic activity via an efficient photoenergy transfer from antenna molecules to the fullerene derivative. The photodynamic activity was found to be much higher than those of dyad systems using pristine C 60 and C 70 .