Synthesis and HNO Donating Properties of the Piloty's Acid Analogue Trifluoromethanesulphonylhydroxamic Acid: Evidence for Quantitative Release of HNO at Neutral pH Conditions | Zendy

Adas Sonya K. | Zendy; Bharadwaj Vinay | Zendy; Zhou Yang | Zendy; Zhang Jiuhong | Zendy; Seed Alexander J. | Zendy; Brasch Nicola E. | Zendy; Sampson Paul | Zendy

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Synthesis and HNO Donating Properties of the Piloty's Acid Analogue Trifluoromethanesulphonylhydroxamic Acid: Evidence for Quantitative Release of HNO at Neutral pH Conditions

Author(s) -

Adas Sonya K.,

Bharadwaj Vinay,

Zhou Yang,

Zhang Jiuhong,

Seed Alexander J.,

Brasch Nicola E.,

Sampson Paul

Publication year - 2018

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201800662

Subject(s) - aqueous solution , chemistry , molecule , inorganic chemistry , nuclear chemistry , organic chemistry

Trifluoromethanesulphonylhydroxamic acid, CF 3 SO 2 NHOH, is shown to release HNO under physiological pH conditions. A two‐step synthesis is presented with the first complete characterization of CF 3 SO 2 NHOH. This molecule rapidly decomposes in neutral aqueous solution to cleanly release HNO and CF 3 SO 2 − , which was demonstrated using the HNO traps TXPTS and HOCbl, and by 19 F NMR spectroscopy.

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