Palladium‐Catalyzed Asymmetric Allylic Alkylation of 4‐Substituted Isoxazolidin‐5‐ones: Straightforward Access to β 2,2 ‐Amino Acids | Zendy

Nascimento de Oliveira Marllon | Zendy; Arseniyadis Stellios | Zendy; Cossy Janine | Zendy

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Palladium‐Catalyzed Asymmetric Allylic Alkylation of 4‐Substituted Isoxazolidin‐5‐ones: Straightforward Access to β 2,2 ‐Amino Acids

Author(s) -

Nascimento de Oliveira Marllon,

Arseniyadis Stellios,

Cossy Janine

Publication year - 2018

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201800641

Subject(s) - stereocenter , tsuji–trost reaction , palladium , enantioselective synthesis , catalysis , alkylation , chemistry , allylic rearrangement , amino acid , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry

We report here an unprecedented and highly enantioselective palladium‐catalyzed allylic alkylation applied to 4‐substituted isoxazolidin‐5‐ones. Ultimately, the process provides a straightforward access to β 2,2 ‐amino acids bearing an all‐carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity.

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