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Nickel‐Catalyzed Alkylarylation of Activated Alkenes with Benzyl‐amines via C−N Bond Activation
Author(s) -
Yu Hui,
Hu Bin,
Huang Hanmin
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800543
Subject(s) - chemistry , catalysis , moiety , amine gas treating , nickel , alkyl , redox , medicinal chemistry , polymer chemistry , photochemistry , organic chemistry
A nickel‐catalyzed alkylarylation of active alkenes with tertiary benzylamines was achieved by charge‐transfer‐complex promoted C−N bond activation. The reaction proceeded through initial Ni‐catalyzed C−N bond activation, followed by sequential radical addition, redox and proton abstraction with cleaved amine moiety in the absence of oxidant, and provides an efficient method to prepare various alkyl‐substituted oxindoles and dihydroquinolinones in good yields.