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Arene‐Ligand‐Free Ruthenium(II/III) Manifold for meta ‐C−H Alkylation: Remote Purine Diversification
Author(s) -
Fumagalli Fernando,
Warratz Svenja,
Zhang ShouKun,
Rogge Torben,
Zhu Cuiju,
Stückl A. Claudia,
Ackermann Lutz
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800530
Subject(s) - ruthenium , chemistry , alkylation , ligand (biochemistry) , catalysis , purine , combinatorial chemistry , stereochemistry , medicinal chemistry , enzyme , organic chemistry , biochemistry , receptor
meta ‐Selective C−H alkylations of bioactive purine derivatives were accomplished by versatile ruthenium catalysis. Thus, the arene‐ligand‐free complex [Ru(OAc) 2 (PPh 3 ) 2 ] enabled remote C−H functionalizations with ample scope and excellent levels of chemo‐ and positional selectivities. Detailed experimental and computational mechanistic studies provided strong support for a facile C−H activation within a ruthenium(II/III) manifold.