Arene‐Ligand‐Free Ruthenium(II/III) Manifold for  meta ‐C−H Alkylation: Remote Purine Diversification | Zendy

Fumagalli Fernando | Zendy; Warratz Svenja | Zendy; Zhang ShouKun | Zendy; Rogge Torben | Zendy; Zhu Cuiju | Zendy; Stückl A. Claudia | Zendy; Ackermann Lutz | Zendy

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Arene‐Ligand‐Free Ruthenium(II/III) Manifold for meta ‐C−H Alkylation: Remote Purine Diversification

Author(s) -

Fumagalli Fernando,

Warratz Svenja,

Zhang ShouKun,

Rogge Torben,

Zhu Cuiju,

Stückl A. Claudia,

Ackermann Lutz

Publication year - 2018

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201800530

Subject(s) - ruthenium , chemistry , alkylation , ligand (biochemistry) , catalysis , purine , combinatorial chemistry , stereochemistry , medicinal chemistry , enzyme , organic chemistry , biochemistry , receptor

meta ‐Selective C−H alkylations of bioactive purine derivatives were accomplished by versatile ruthenium catalysis. Thus, the arene‐ligand‐free complex [Ru(OAc) 2 (PPh 3 ) 2 ] enabled remote C−H functionalizations with ample scope and excellent levels of chemo‐ and positional selectivities. Detailed experimental and computational mechanistic studies provided strong support for a facile C−H activation within a ruthenium(II/III) manifold.

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