Premium
Intracellular Chemistry: Integrating Molecular Inorganic Catalysts with Living Systems
Author(s) -
Ngo Anh H.,
Bose Sohini,
Do Loi H.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800504
Subject(s) - biomolecule , chemistry , catalysis , cycloaddition , combinatorial chemistry , intracellular , alkyne , nanotechnology , molecule , small molecule , hydrolysis , heterogeneous catalysis , organic chemistry , materials science , biochemistry
This concept article focuses on the rapid growth of intracellular chemistry dedicated to the integration of small‐molecule metal catalysts with living cells and organisms. Although biological systems contain a plethora of biomolecules that can deactivate inorganic species, researchers have shown that small‐molecule metal catalysts could be engineered to operate in heterogeneous aqueous environments. Synthetic intracellular reactions have recently been reported for olefin hydrogenation, hydrolysis/oxidative cleavage, azide‐alkyne cycloaddition, allylcarbamate cleavage, C−C bond cross coupling, and transfer hydrogenation. Other promising targets for new biocompatible reaction discovery will also be discussed, with a special emphasis on how such innovations could lead to the development of novel technologies and chemical tools.