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Cover Feature: Silver(I)‐Mediated Base Pairs in DNA Sequences Containing 7‐Deazaguanine/Cytosine: towards DNA with Entirely Metallated Watson–Crick Base Pairs (Chem. Eur. J. 18/2018)
Author(s) -
MéndezArriaga José M.,
Maldonado Carmen R.,
Dobado José A.,
Galindo Miguel A.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800442
Subject(s) - molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , base pair , nucleobase , dna , chemistry , cytosine , molecule , guanine , crystallography , stereochemistry , helix (gastropod) , nucleotide , biology , biochemistry , organic chemistry , gene , ecology , snail
This work shows the metallation of DNA molecules containing Watson–Crick base pairs 7C G‐C, where the guanine nucleobase has been replaced by its 7‐deazapurine analogue. These deaza‐DNA molecules can be initially assembled by using the Watson–Crick pairing rules, and the addition of silver(I) ions leads to the formation of silver–DNA molecules, comprising 7C G–Ag I –C base pairs, that preserve their initial double helix B‐conformation. This strategy, together with the generation of 7C A–Ag I –T base pairs, can be employed to prepare silver–DNA systems by using their sequence programmability. More information can be found in the Full Paper by M. A. Galindo et al. on page 4583.