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Premium Self‐Assembling of Fmoc‐GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates
Author(s)
Avitabile Concetta,
Diaferia Carlo,
Della Ventura Bartolomeo,
Mercurio Flavia Anna,
Leone Marilisa,
Roviello Valentina,
Saviano Michele,
Velotta Raffaele,
Morelli Giancarlo,
Accardo Antonella,
Romanelli Alessandra
Publication year2018
Publication title
chemistry – a european journal
Resource typeJournals
Abstract The study of molecules that self‐assemble through noncovalent interactions is one of the most attractive topics in supramolecular chemistry. The use of short peptides or modified nucleotides as building blocks for the aggregates is particularly intriguing because these are very easy to synthesize; moreover, subtle changes in the chemical structure of such building blocks may drastically affect the properties of the aggregates. The ability of peptide nucleic acids (PNA) to aggregate has been very little explored, despite its practical applications. In this work we investigated the self‐assembling properties of a PNA dimer, conjugated at the N‐terminus to a fluorenylmethoxycarbonyl group. This PNA dimer forms nano‐aggregates at low concentration in CHCl 3 /CH 3 OH mixtures. The aggregates retain very interesting fluorescent properties (high quantum yield in the visible region with lifetimes on the nanosecond scale), which make them promising materials for applications in optoelectronics.
Subject(s)biochemistry , chemistry , combinatorial chemistry , conjugated system , dimer , fluorescence , gene , materials science , molecule , nanotechnology , nucleic acid , nucleotide , organic chemistry , peptide , peptide nucleic acid , physics , polymer , quantum mechanics , self assembly , supramolecular chemistry
Language(s)English
SCImago Journal Rank1.687
H-Index242
eISSN1521-3765
pISSN0947-6539
DOI10.1002/chem.201800279

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