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Self‐Assembly of a Guanosine Derivative To Form Nanostructures and Transmembrane Channels
Author(s) -
Das Rabindra Nath,
Kumar Y. Pavan,
Kumar S. Arun,
Schütte Ole Mathis,
Steinem Claudia,
Dash Jyotirmayee
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800205
Subject(s) - bilayer , nanostructure , membrane , self assembly , lipid bilayer , materials science , stacking , nanotechnology , crystallography , chemistry , organic chemistry , biochemistry
We herein report the self‐assembly of a lipophilic bromoguanosine derivative ( G1 ) in homogeneous solution, in the solid state and in planar bilayer membranes. The self‐assembly of G1 , driven by H‐bonding and π–π stacking interactions can form different nano‐structures depending on incubation time. The G1 nanostructure is able to bind a bioactive dye like Rose Bengal. In crystal state, it shows ribbon type H‐bonding pattern and exhibits birefringence in polarized light. And further, the self‐assembled nanostructure of G1 can form discrete transmembrane ion channels in lipid bilayer membranes, enabling passage of potassium ions.