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The Generation of Diazo Compounds in Continuous‐Flow
Author(s) -
Hock Katharina J.,
Koenigs Rene M.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800136
Subject(s) - diazo , continuous flow , scalability , computer science , explosive material , biochemical engineering , flow chemistry , class (philosophy) , process engineering , combinatorial chemistry , risk analysis (engineering) , nanotechnology , environmental science , chemistry , business , materials science , engineering , database , organic chemistry , artificial intelligence
Toxic, cancerogenic and explosive—these attributes are typically associated with diazo compounds. Nonetheless, diazo compounds are nowadays a highly demanded class of reagents for organic synthesis, yet the concerns with regards to safe and scalable transformations of these compounds are still exceptionally high. Lately, the research area of the continuous‐flow synthesis of diazo compounds attracted significant interest and a whole variety of protocols for their “on‐demand” preparation have been realized to date. This concept article focuses on the recent developments using continuous‐flow technologies to access diazo compounds; thus minimizing risks and hazards when working with this particular class of compounds. In this article we discuss these concepts and highlight different pre‐requisites to access and to perform downstream functionalization reaction.