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Remote C−H Activation of Various N‐Heterocycles Using a Single Template
Author(s) -
Yang Guoqiang,
Zhu Dajian,
Wang Peng,
Tang RiYuan,
Yu JinQuan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800105
Subject(s) - benzonitrile , combinatorial chemistry , selectivity , ring (chemistry) , simple (philosophy) , chemistry , computer science , catalysis , organic chemistry , philosophy , epistemology
A single and simple ortho ‐sulfonyl benzonitrile template was developed to achieve remote C−H olefination of six different classes of N‐heterocycles. We demonstrate that, by varying precatalysts and conditions, the same template can be applied to the remote C−H activation of six structurally distinct heterocyclic scaffolds, and the site‐selectivity can be predicted based on distance and geometry. Furthermore, this new development shows that template‐directed remote C−H activation is possible through macrocyclopalladation processes with smaller ring sizes.