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Tuning Mg(II) Selectivity: Comparative Analysis of the Photophysical Properties of Four Fluorescent Probes with an Alkynyl‐Naphthalene Fluorophore
Author(s) -
Walter Edward R. H.,
Williams J. A. Gareth,
Parker David
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800013
Subject(s) - selectivity , fluorescence , chemistry , fluorophore , phosphinate , magnesium , dissociation constant , carboxylate , zinc , naphthalene , fluorescence spectroscopy , photochemistry , ionophore , ion , dissociation (chemistry) , inorganic chemistry , chelation , calcium , stereochemistry , organic chemistry , biochemistry , physics , receptor , fire retardant , quantum mechanics , catalysis
Four alkynyl‐1‐naphthyl fluorophores have been synthesised with tri‐ or pentadentate ligating groups suited to the binding of magnesium. Their photophysical and binding properties for magnesium, calcium and zinc ions have been assessed using absorption, emission and excitation spectroscopy. Each compound has a p K a value between 6.2 and 5.1 and exhibits no significant pH response around pH 7.2. Enhanced selectivity for Mg 2+ over Ca 2+ was observed with a pentadentate phosphinate substituted system, compared to its carboxylate analogue, due to a 10‐fold lowering of affinity for the Ca 2+ ion. In each case, the overall dissociation constants for Mg 2+ fall in the low m m range.