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Frontispiece: Achieving High 1 H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds
Author(s) -
Norcott Philip,
Rayner Peter J.,
Green Gary G. R.,
Duckett Simon B.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201786764
Subject(s) - hyperpolarization (physics) , spin isomers of hydrogen , nuclear magnetic resonance , labelling , chemistry , relaxation (psychology) , nuclear magnetic resonance spectroscopy , physics , medicine , biochemistry , hydrogen , organic chemistry
The nuclear magnetic resonance (NMR) detectability of several TB‐relevant agents have been significantly improved through the use of the parahydrogen‐based hyperpolarization protocol signal amplification by reversible exchange (SABRE) in conjunction with the 2 H‐labelling of key sites within their molecular structures and the 2 H‐labelling of the magnetization‐transfer catalyst. The T 1 relaxation times and polarization levels of these agents are quantified under test conditions to produce a protocol to identify structurally optimized motifs for future detection in MRI. For more information see the Full Paper by S. B. Duckett et al. on page 16990 ff.