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Frontispiece: Tuning Electron Flux through Nitrogenase with Methanogen Iron Protein Homologues
Author(s) -
Hiller Caleb J.,
Stiebritz Martin T.,
Lee Chi Chung,
Liedtke Jasper,
Hu Yilin
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201786463
Subject(s) - nitrogenase , methanogen , cofactor , electron transport chain , enzyme , electron , chemistry , electron transfer , flux (metallurgy) , electron flow , biochemistry , biophysics , biology , nitrogen fixation , photochemistry , bacteria , physics , genetics , photosynthesis , organic chemistry , quantum mechanics
A homologue‐based approach facilitates capture of multiple CO molecules at the nitrogenase cofactor site via reduction of the electron flow through a nitrogenase hybrid between homologous component proteins, suggesting the utility of this approach in tuning electron fluxes to enable trapping of substrates and relevant intermediates for mechanistic investigations of this enzyme. For more information, see the Communication by Y. Hu et al. on page 16152 ff.