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Frontispiece: Regioselective Direct C‐Alkenylation of Indoles
Author(s) -
Petrini Marino
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201786462
Subject(s) - regioselectivity , moiety , indole test , nitrogen atom , reactivity (psychology) , chemistry , surface modification , combinatorial chemistry , catalysis , medicinal chemistry , stereochemistry , organic chemistry , group (periodic table) , medicine , alternative medicine , pathology
The regioselective introduction of an alkenyl moiety on indoles can be achieved by exploiting the intrinsic reactivity of this heterocycle toward C‐3 substitution. Conversely, the appropriate functionalization of the indole nitrogen atom allows to direct the alkenylation at C‐2. Metal‐catalyzed C−H activation and reaction with alkenes, hydroindolation of alkynes and condensation reactions with carbonyl derivatives are the main procedures adopted for the alkenylation of indoles. For more information see the Review article by M. Petrini on page 16115 ff.