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Frontispiece: Biosynthesis and Total Synthesis of Pyrronazol B: a Secondary Metabolite from Nannocystis pusilla
Author(s) -
Witte Swjatoslaw N. R.,
Hug Joachim J.,
Géraldy Magalie N. E.,
Müller Rolf,
Kalesse Markus
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201786364
Subject(s) - moiety , oxazole , biosynthesis , secondary metabolite , metabolite , total synthesis , modular design , stereochemistry , chemistry , biochemistry , computer science , gene , programming language
Both the biosynthesis as well as the chemical synthesis of pyrronazol follow a modular approach starting with a pyrrole building block. This secondary metabolite was isolated from Nannocystis pusilla Ari7 and both routes utilize modular extensions to introduce an oxazole moiety and to generate the unsaturated lactone through ester condensation steps. For more information see the Full Paper by M. Kalesse et al. on page 15917 ff.