Premium
Frontispiece: Catalytic Metallodrugs: Substrate‐Selective Metal Catalysts as Therapeutics
Author(s) -
Yu Zhen,
Cowan James A.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201785762
Subject(s) - catalysis , chemistry , nanotechnology , substrate (aquarium) , biomolecule , combinatorial chemistry , materials science , biochemistry , biology , ecology
Advances in the design and application of catalytic metallodrugs are highlighted in the Review by Z. Yu and J. A. Cowan on page 14113 ff., and approaches to the design of catalytic metallodrugs that selectively target a therapeutically relevant biomolecule are discussed. Incorporation of a recognition domain into catalytic metallodrugs improves substrate selectivity and many examples of catalytic metallodrugs that selectively inactivate or degrade nucleic acid, protein, or other biomolecular targets are described.