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Frontispiece: Control of Helical Chirality of Ferrocene–Dipeptide Conjugates by the Secondary Structure of Dipeptide Chains
Author(s) -
Moriuchi Toshiyuki,
Nishiyama Taiki,
Nobu Masaki,
Hirao Toshikazu
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201785263
Subject(s) - chirality (physics) , antiparallel (mathematics) , dipeptide , ferrocene , chemistry , axial chirality , stereochemistry , crystallography , enantioselective synthesis , amino acid , catalysis , organic chemistry , physics , biochemistry , chiral symmetry breaking , electrode , quantum mechanics , magnetic field , nambu–jona lasinio model , electrochemistry , quark
The helical chirality of a series of ferrocene‐dipeptide bioorganometallic conjugates could be controlled by cyclic/acyclic conversion. The suitable regulation of the conformational flexibility allowed a type II β ‐turn‐type second structure to be formed, thus inducing M ‐helical chirality. Furthermore, the conversion of a type II β ‐turn‐like structure to an antiparallel β ‐sheet‐like structure was achieved through the reductive cleavage of the disulfide bond to thiol groups, leading to the conversion of M ‐helical chirality into P ‐helical chirality. For more details, see the Communcation by T. Moriuchi et al. on page 12704 ff.