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Frontispiece: Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation
Author(s) -
Schnepel Christian,
Sewald Norbert
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201785065
Subject(s) - halogenation , regioselectivity , electrophile , chemistry , combinatorial chemistry , surface modification , catalysis , substrate (aquarium) , organic chemistry , biology , ecology
C−H functionalization belongs to the most challenging topics of synthetic chemistry due to the dilemma of substrate vs. catalyst control. Remarkably, halogenating enzymes provide a “green” approach for site‐selective C–H functionalization that is often superior to conventional methodologies. Only molecular oxygen and halide salts are required for highly selective electrophilic halogenation under ambient conditions. Recently considerable efforts were made to enhance the preparative utility of halogenating enzymes. The application scope was expanded towards more robust biocatalysts enabling enzymatic halogenation of a wide range of arenes. Timely developments of biohalogenation regarding preparative synthesis, engineering and cascade processes are being discussed in the minireview by C. Schnepel and N. Sewald on page 12064 ff.