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Frontispiece: A Retrosynthesis Approach for Biocatalysis in Organic Synthesis
Author(s) -
de Souza Rodrigo O. M. A.,
Miranda Leandro S. M.,
Bornscheuer Uwe T.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201785064
Subject(s) - biocatalysis , retrosynthetic analysis , sitagliptin , chemistry , biochemical engineering , combinatorial chemistry , stereochemistry , organic chemistry , engineering , biology , microbiology and biotechnology , catalysis , total synthesis , reaction mechanism , metformin , insulin
The retrosynthetic concepts using enzymes as biocatalysts described for C−N, C−O and C−C bond formations are highlighted. A range of examples for the combination of biocatalysis with chemical reactions is illustrated for the synthesis of drugs and APIs such as Crispine A, Sitagliptin or Atorvastatin. For more details, see the Review by R. O. M. A. de Souza, L. S. M. Miranda and U. T. Bornscheuer on page 12040 ff.