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Frontispiece: Gold(I)‐Catalysed Asymmetric Hydroamination of Alkenes: A Silver‐ and Solvent‐Dependent Enantiodivergent Reaction
Author(s) -
Abadie MarcAntoine,
Trivelli Xavier,
Medina Florian,
Duhal Nathalie,
Kouach Mostafa,
Linden Bernhard,
Génin Eric,
Vandewalle Maxence,
Capet Frédéric,
Roussel Pascal,
Del Rosal Iker,
Maron Laurent,
AgbossouNiedercorn Francine,
Michon Christophe
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201784564
Subject(s) - hydroamination , chemistry , bimetallic strip , alkene , reagent , solvent , organic chemistry , toluene , medicinal chemistry , catalysis
In the background is featured Ginkakuji (Silver Pavilion), a Zen temple along Kyoto′s eastern mountains (Higashiyama) in Japan. In the foreground is featured a chemistry sketch based on the Yin and Yang symbol. As many possible dualities (such as light and dark, fire and water…) are thought of as physical manifestations of the duality symbolised by Yin and Yang, parallels can be drawn with organic chemistry and the gold(I)‐catalysed asymmetric hydroamination of alkenes. An enantiodivergent reaction is possible depending on the presence of silver. Whereas a gold‐catalysed hydroamination reaction afforded ( S )‐product in toluene, the use of methanol led to an enantioinversion and the generation of ( R )‐product through solvation of silver and bimetallic activation of the amino‐alkene reagent. For more information see the Full Paper by F. Agbossou‐Niedercorn, C. Michon and co‐workers on page 10777 ff.