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Frontispiece: Sulfur–Fluoride Exchange (SuFEx)‐Mediated Synthesis of Sterically Hindered and Electron‐Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates
Author(s) -
Smedley Christopher J.,
Barrow Andrew S.,
Spiteri Christian,
Giel MarieClaire,
Sharma Pallavi,
Moses John E.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201784262
Subject(s) - fluoride , steric effects , chemistry , sulfur , organic chemistry , combinatorial chemistry , inorganic chemistry
The development of “SuFExAmide” : A new sulfur–fluoride exchange (SuFEx) click chemistry based protocol for the efficient amidation of carboxylic acids via acyl fluoride intermediates is described. Benzene‐1,3‐disulfonyl fluoride has been synthesized as a cost effective, powerful and versatile coupling agent, which delivers challenging secondary and tertiary amides in excellent yields from sterically hindered and electron‐deficient amines. For more details, see the Communication by J. E. Moses et al on page 9990 ff.