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Frontispiece: Modern Aspects of the Smiles Rearrangement
Author(s) -
Holden Catherine M.,
Greaney Michael F.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201783861
Subject(s) - smiles rearrangement , heteroatom , aryl , chemistry , key (lock) , computer science , combinatorial chemistry , stereochemistry , organic chemistry , computer security , ring (chemistry) , alkyl
The Smiles rearrangement has been revived in the recent literature as a method of preparing diverse sets of molecules containing aryl functionality. Recent progress in heteroatom arylation, in particular, has been a key enabling step for this chemistry, as O, N and S‐arylation can now be reliably achieved to set‐up aryl transfer through Smiles processes. In their Minireview on page 8992 ff., C. M. Holden and M. F. Greaney discuss recent advances in Smiles chemistry.