Premium
Frontispiece: Decarboxylation as the Key Step in C−C Bond‐Forming Reactions
Author(s) -
Patra Tuhin,
Maiti Debabrata
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201783161
Subject(s) - decarboxylation , electrophile , reagent , nucleophile , chemistry , aryl , alkyl , carboxylic acid , catalysis , combinatorial chemistry , organic chemistry , medicinal chemistry
Use of greener and cheaper alternatives in place of conventional organometallic reagents in C−C bond formation is a rapidly growing field of research. Carboxylic acid is an exciting choice in this regard, since it can form the same aryl/alkyl metal intermediate by extrusion of CO 2 . Most importantly, the same carboxylic acid can be used to generate either nucleophilic or radical or electrophilic equivalents by employing different catalytic systems under different reaction conditions. Compiling all these pathways, this review includes all important and recent developments in the field of decarboxylative C−C bond forming reactions. For more details, see the Review by D. Maiti and T. Patra on page 7382 ff.