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Frontispiece: Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment
Author(s) -
Villaverde Gonzalo,
Nairi Valentina,
Baeza Alejandro,
ValletRegí María
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201783062
Subject(s) - moiety , cancer research , cancer cell , sequence (biology) , chemotherapy , cancer , chemistry , biology , medicine , biochemistry , stereochemistry
The efficacy of conventional chemotherapy is severely compromised by the associated systemic toxicity caused by lack of selectivity. In this work, we propose a novel double sequential encrypted targeting system that contains an active primary targeting group able to recognize the target tissue (bone) and an encrypted or hidden secondary targeting moiety able to recognize malignant cells that populate the diseased tissue. Once the system reaches the tumoral place, the presence of a characteristic enzyme naturally overproduced by malignant cells (cathepsin K) provokes the activation of the cellular targeting moiety inducing the uptake within the diseased cells. For more information, see the Communication by Vallet‐Regí et al. on page 7174 ff.