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Frontispiece: The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study
Author(s) -
GarcíaMoreno M. Isabel,
OrtegaCaballero Fernando,
RísquezCuadro Rocío,
Ortiz Mellet Carmen,
García Fernández José M.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201782663
Subject(s) - lectin , chemistry , glycoside hydrolase , computational biology , biochemistry , biology , enzyme
A “generalized multivalent effect” operates in recognizing sugar or glycomimetic structures by lectins and glycosidases, evidenced by the binding/inhibition/cross‐linking abilities of a series of designed cyclodextrin (hetero)conjugates. New binding modes that differ significantly from those of monovalent ligands and synergistic/antagonistic effects were characterized, providing a rationale for the multimodal changes in recognition patterns orchestrated by (hetero)multivalency. For more information, see the Full Paper by C. Ortiz Mellet, J. M. Garcia Fernandez, et al. on page 6295 ff.