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Frontispiece: Protection of Endogenous Thiols against Methylmercury with Benzimidazole‐Based Thione by Unusual Ligand‐Exchange Reactions
Author(s) -
Banerjee Mainak,
Karri Ramesh,
Chalana Ashish,
Das Ranajit,
Rai Rakesh Kumar,
Rawat Kuber Singh,
Pathak Biswarup,
Roy Gouriprasanna
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201782463
Subject(s) - chemistry , benzimidazole , thiol , cysteine , ligand (biochemistry) , glutathione , substituent , endogeny , stereochemistry , cytotoxicity , combinatorial chemistry , biochemistry , organic chemistry , in vitro , receptor , enzyme
The cytotoxicity of MeHg + species is shown through strong binding with endogenous thiols such as cysteine (CysH) and glutathione (GSH) to form MeHgCys and MeHgSG complexes. A novel benzimidazole‐based thione molecule with N‐CH 2 CH 2 OH substituent has been discovered, which exhibits remarkable effect in converting MeHgCys and MeHgSG to water‐soluble HgS snanoparticles and releases the corresponding free thiol (CysH or GSH) via unusual ligand exchange reactions. For more information, see the Full Paper by Gouriprasanna Roy et al. on page 5696 ff.