Premium
Frontispiece: Recent Progress Toward the Synthesis of Trifluoromethyl‐ and Difluoromethyl‐Substituted Cyclopropanes
Author(s) -
Bos Maxence,
Poisson Thomas,
Pannecoucke Xavier,
Charette André B.,
Jubault Philippe
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201782161
Subject(s) - cyclopropane , bioisostere , trifluoromethyl , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , ring (chemistry) , chemical synthesis , biochemistry , alkyl , in vitro
Synthetic Methods The trifluoromethylated cyclopropane is considered as fluorinated bioisostere of the tert ‐butyl group, while the difluoromethylated one could act as a mimic of the cyclopropanol motif. In this article, the most important recent developments toward the synthesis of such scaffolds are summarized. For more details, see the Minireview by A. B. Charette, P. Jubault et al. on page 4950 ff.