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Frontispiece: Anion–π Interactions in Flavoproteins Involve a Substantial Charge‐Transfer Component
Author(s) -
Yurenko Yevgen P.,
Bazzi Sophia,
Marek Radek,
Kozelka Jiří
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201781462
Subject(s) - flavoprotein , flavin group , ion , charge (physics) , component (thermodynamics) , chemistry , redox , electron transfer , flavin adenine dinucleotide , chemical physics , photochemistry , physics , biochemistry , enzyme , inorganic chemistry , cofactor , organic chemistry , quantum mechanics
Anion–π interactions are commonly attributed to electrostatic forces between an anion and the electropositive region at the π‐face of an electron‐deficient arene. The authors present a multiapproach theoretical analysis which indicates that anion‐flavin interactions operating in flavoproteins are not purely electrostatic but involve a substantial charge‐transfer component. This finding sheds new light at the regulation of the redox properties of the co‐factors FAD and FMN, and suggests that anion–π interactions should not be considered as generally noncovalent. For more details, see the Communication J. Kozelka et al. on page 3246 ff.