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Frontispiece: Synchrotron X‐Ray Fluorescence Nanoprobe Reveals Target Sites for Organo‐Osmium Complex in Human Ovarian Cancer Cells
Author(s) -
SanchezCano Carlos,
RomeroCanelón Isolda,
Yang Yang,
HandsPortman Ian J.,
Bohic Sylvain,
Cloetens Peter,
Sadler Peter J.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201781162
Subject(s) - nanoprobe , osmium , chemistry , fluorescence , synchrotron , biochemistry , physics , optics , ruthenium , catalysis
Organometallic Complexes Metallodrug targets in cells: Organo‐osmium arene complexes can exhibit potent anticancer activity. It is now important to elucidate their mechanism of action by identifying their target sites. In their Communication on page 2512 ff., P. J. Sadler et al show that the ESRF synchrotron ID16A beamline nanoprobe allows organo‐osmium to be mapped by X‐ray fluorescence with high special resolution and sensitivity in subcellular organelles of cancer cells at pharmacologically‐relevant doses, as well as its effect on the distribution of natural elements such as P, Ca and Zn. The authors thank P. JAYET and ESRF for permission to reproduce the photograph in the lower panel.