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Frontispiece: Small‐Molecule Carbohydrate‐Based Immunostimulants
Author(s) -
Marzabadi Cecilia H.,
Franck Richard W.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201780861
Subject(s) - receptor , carbohydrate , toll , immune system , small molecule , toll like receptor , immunotherapy , glycan , vaccine adjuvant , chemistry , biology , biochemistry , immunology , microbiology and biotechnology , computational biology , innate immune system , glycoprotein
Immune Receptors Low‐molecular‐weight carbohydrate‐based ligands for Toll‐like receptor 4 (TLR‐4) and cluster of differentiation 1D (CD1d) are showing increasing prominence in immunotherapy and as vaccine adjuvants. In this paper by Marzabadi and Franck, strategies for preparing analogues and novel ligands for these receptors is discussed. Clinical data for some of the compounds is also described. For further details, see the Minireview on page 1728 ff.